海角社区

Sam Hess

Professor
Physics and Astronomy

Recent Presentations

鈥淪uper-Resolution Microscopy: Illuminating Biological Functions to Cure Disease,鈥 Science Seminar Series, Emera Astronomy Center, University of 海角社区, Orono, ME, September 2019.

鈥淟ocalization Microscopy: Technological Advances Coupled to Biological Applications鈥 Keynote Lecture, Molecular Biophysics Training Program, Cornell University, Ithaca, NY, November 2019.

鈥淪uper-Resolution Microscopy Quantifies Interactions between Influenza Hemagglutinin, Actin, and PIP2,鈥 Department of Chemistry, Yale University, New Haven, CT, May 2019.

鈥淟ocalization Microscopy: Methodological Advances for Biological Applications,鈥 Gordon Research Conference 鈥淪ingle Molecule Approaches to Biology,鈥 Mt. Snow, Vermont, July 2018.

鈥淭he Role of Probe Photophysics in Localization-Based Superresolution Microscopy,鈥 Biophysical Society Annual Meeting, San Francisco, CA, February 2018.

鈥淟ocalization Microscopy: Technological Advances Coupled to Biological Advances,鈥 National Institute of Biomedical Imaging and Biotechnology, National Institutes of Health, Bethesda, MD, November 2016.

鈥淟ocalization-Based Superresolution Microscopy: Principles and Biological Applications,鈥 Edinburgh Super-Resolution Imaging Consortium (ESRIC) Summer School, Edinburgh, Scotland, August, 2016.

鈥淟ocalization-Based Superresolution Microscopy: Biological Applications,鈥 lecture for the International School of Biophysics Antonio Borsellino, 43rd Course: Nanoscale biophysics: focus on methods and techniques, Directed by A. Diaspro and P. Bianchini, Erice, Sicily, April 21, 2016.

鈥淟ocalization-Based Superresolution Microscopy: Principles,鈥 lecture for the International School of Biophysics Antonio Borsellino, 43rd Course: Nanoscale biophysics: focus on methods and techniques, Directed by A. Diaspro and P. Bianchini, Erice, Sicily, April 19, 2016.

Slattery, Lucinda K., Zackery B. McClelland, and Samuel T. Hess. 2024. 鈥淧rocess鈥揝tructure鈥揚roperty Relationship Development in Large-Format Additive Manufacturing: Fiber Alignment and Ultimate Tensile Strength鈥 Materials 17, no. 7: 1526.

Sandberg, Amanda L., Avery C. S. Bond, Lucas J. Bennett, Sophie E. Craig, David P. Winski, Lara C. Kirkby, Abby R. Kraemer, Kristina G. Kelly, Samuel T. Hess, and Melissa S. Maginnis. 2024. 鈥淕PCR Inhibitors Have Antiviral Properties against JC Polyomavirus Infection鈥 Viruses 16, no. 10: 1559. 

鈥淐onserved sequence features in intracellular domains of viral spike proteins,鈥 Vinh-Nhan Ngo, David P. Winski, Brandon Aho, Pauline L. Kamath, Benjamin L. King, Hang Waters, Joshua Zimmerberg, Alexander Sodt, Samuel T. Hess, Virology, Volume 599, 2024, 110198, ISSN 0042-6822,

鈥淧hosphatidylinositol 4,5-Bisphosphate Mediates the Co-Distribution of Influenza A Hemagglutinin and Matrix Protein M1 at the Plasma Membrane,鈥 P. Raut, B. Obeng, H. Waters, J. Zimmerberg, J. Gosse, and S.T. Hess, Viruses 14(11):2509 (2022).

鈥淒ynamics and Patterning of 5-Hydroxytryptamine 2 Subtype Receptors in JC Polyomavirus Entry,鈥 K. Mehmood, M.P. Wilczek, J.K. DuShane, M.T. Parent, C.L. Mayberry, J.N. Wallace, F.L. Levasseur, T.M. Fong, S.T. Hess, and M.S. Maginnis, Viruses 14(12): 2597 (2022).

鈥淟ocalization-Based Super-Resolution Microscopy Reveals Relationship between SARS-CoV2 Spike and Phosphatidylinositol (4,5)-bisphosphate,鈥 P. Raut, H. Waters, J. Zimmberberg, B. Obeng, J. Gosse, and S.T. Hess, Proc. of SPIE Vol. 11965: 1196503, 1605-7422 (2022).

鈥淐etylpyridinium chloride (CPC) reduces zebrafish mortality from influenza infection:  Super-resolution microscopy reveals CPC interference with multiple protein interactions with
phosphatidylinositol 4,5-bisphosphate in immune function,鈥 P. Raut, S.R. Weller, B. Obeng, B.L. Soos, B.E. West, C.M. Potts, S. Sangroula, M. S. Kinney, J.E. Burnell, B.L. King, J.A. Gosse, and S.T. Hess, Toxicology and Applied Pharmacology, 440: 115913 (2022).

鈥淭riclosan disrupts immune cell function by depressing Ca 2+ influx following acidification of the cytoplasm,鈥漇angroula, S., Vasquez, A.Y.,Raut, P., Obeng, B., Shim, J.K., Bagley, G.D., West, B.E., Burnell, J.E., Kinney, M.S., Potts, C.M., Weller, S.R., Kelley, J.B., Hess, S.T., Gosse, J.A.*  Toxicology and Applied Pharmacology 405: 115205, doi: 10.1016/j.taap.2020.115205, 2020. PMID: 32835763

鈥淒etection and Analysis of Uncharged Particles Utilizing Consumer-Grade CCDs,鈥 John A. Cummings, James W. Deaton, Charles T. Hess, Samuel T. Hess,Health Physics Journal118(6):583-592 (2020).

鈥淨uantification of Mitochondrial Membrane Curvature by Three-Dimensional Localization Microscopy,鈥 Matthew Parent and Samuel T. Hess,iScience Notes,4(3): 1-2 (2019).

鈥淚nfluenza Hemagglutinin Modulates Phosphatidylinositol(4,5)bisphosphate (PIP2) Clustering,鈥 Nikki M. Curthoys, Michael J. Mlodzianoski, Matthew Parent, Prakash Raut, Michael B. Butler, Jaqulin Wallace, Jennifer Lilieholm, Kashif Mehmood, Melissa Maginnis, Hang Waters, Brad Busse, Joshua Zimmerberg, and Samuel T. Hess,Biophysical Journal116(5):893-909. doi: 10.1016/j.bpj.2019.01.017 (2019).

鈥淢olecular Imaging with Neural Training of Identification Algorithm (MINuTIA),鈥 A.J. Nelson and S.T. Hess,Microscopy Research and Technique(2018).

鈥淎ntimicrobial Agent Triclosan Disrupts Mitochondrial Structure, Revealed by Super-resolution Microscopy, and Inhibits Mast Cell Signaling via Calcium Modulation Toxicology and Applied Pharmacology,鈥 Lisa M Weatherly, Andrew J. Nelson, Juyoung Shim, Abigail M. Riitano, Erik D. Gerson, Andrew J. Hart, Jaime de Juan-Sanz, Timothy A. Ryan, Roger Sher, Samuel T. Hess, Julie A. Gosse,Toxicololgy and Applied Pharmacology349: 39-54 (2018).

鈥淭otal internal reflection fluorescence based multiplane localization microscopy enables super-resolved volume imaging,鈥 P.P. Mondal, S.T. Hess,Applied Physics Letters110 (21), 211102 (2017).

鈥淭he Role of Probe Photophysics in Localization-Based Superresolution Microscopy,鈥 Francesca Pennacchietti, Travis Gould, and Samuel T. Hess,Biophysical Journal113 (9) 2037鈥2054 (2017).

鈥淎 Cross Beam Excitation Geometry for Localization Microscopy,鈥 Matthew Valles and Samuel T. Hess,iScience NotesDOI:  (2017).

鈥淪pectral Fluorescence Photoactivation Localization Microscopy,鈥 Michael Mlodzianoski, M. S. Gunewardene, and Samuel T. Hess,PLoS One11(3): e0147506 (2016).

鈥淐lean Localization Super-resolution Microscopy for 3D Biological Imaging,鈥 Partha P. Mondal, Nikki M. Curthoys, and Samuel T. Hess,AIP Advances6, 015017 (2016).

鈥淪uper Resolution Fluorescence Localization Microscopy,鈥 Michael J. Mlodzianoski, Matthew M. Valles, Samuel T. Hess, inEncyclopedia of Cell Biology, Ed. Ralph Bradshaw, Philip Stahl and John Heuser & Sergio Grinstein (2016).

鈥淪pectral Fluorescence Photoactivation Localization Microscopy,鈥 Michael Mlodzianoski, M. S. Gunewardene, and Samuel T. Hess, PLoS One 11(3): e0147506 (2016).

鈥淐lean Localization Super-resolution Microscopy for 3D Biological Imaging,鈥 Partha P. Mondal, Nikki M. Curthoys, and Samuel T. Hess, AIP Advances 6, 015017 (2016).

鈥淪uper Resolution Fluorescence Localization Microscopy,鈥 Michael J. Mlodzianoski, Matthew M. Valles, Samuel T. Hess, in Encyclopedia of Cell Biology, Ed. Ralph Bradshaw, Philip Stahl and John Heuser & Sergio Grinstein (2016).

鈥淎ntimicrobial Agent Triclosan is a Proton Ionophore Uncoupler of Mitochondria in Living Rat and Human Mast Cells and in Primary Human Keratinocytes,鈥 Lisa M. Weatherly, Juyoung Shim, Hina N. Hashmi, Rachel H. Kennedy, Samuel T. Hess, and Julie A. Gosse, Journal of Applied Toxicology Jul 23. doi: 10.1002/jat.3209 (2015).

鈥淒ances with Membranes: Breakthroughs from Super-Resolution Imaging,鈥 Nikki M. Curthoys, Matthew Parent, Michael Mlodzianoski, Andrew J. Nelson, Jennifer Lilieholm, Michael B. Butler, Matthew Valles, and Samuel T. Hess, in Current Topics in Membranes, Ed. Anne Kenworthy (2015).

鈥淣anoscale Imaging of Caveolin-1 Membrane Domains in vivo,鈥 Kristin A. Gabor, Dahan Kim, Carol H. Kim, and Samuel T. Hess, PLoS One 10(2): e0117225 (2015).

鈥淐ombining Total Internal Reflection Sum Frequency Spectroscopy Spectral Imaging and Confocal Fluorescence Microscopy,鈥 Edward S. Allgeyer, Sarah M. Sterling, Mudalige S. Gunewardene, Samuel T. Hess, David J. Neivandt, and Michael D. Mason, Langmuir 31 (3): 987-994 (2015).

鈥淧recisely and accurately localizing single emitters in fluorescence microscopy: state-of-the-art and best practice,鈥 Hendrik Deschout, Francesca Cella Zanacchi, Michael Mlodzianoski*, Alberto Diaspro, Joerg Bewersdorf, Samuel T. Hess, and Kevin Braeckmans, Nature Methods, accepted.

Areas of Expertise

Experimental and Theoretical Biophysics
Fluorescence Microscopy and Spectroscopy
Green Fluorescent Proteins
Single Molecule Fluorescence Photophysics

Education

Ph.D., Physics, Cornell University, 2002
M.S., Physics, Cornell University, 1998
B.S., Physics, Yale University, 1995
Portrait of Sam Hess
Professor
Member, GSBSE
Cooperating Professor of Chemistry
Graduate Coordinator